Epithelial plasticity, stemness and pluripotency

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Meng-Ju Wu1,2, Yu-Syuan Chen1,2, Mi Ran Kim1,2 and Chun-Ju Chang1,2* 1Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, USA 2Center for Cancer Research, Purdue University, West Lafayette, USA *Corresponding author: Chun-Ju Chang, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 4790...

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Induced pluripotent stem (iPS) cells are a valuable resource for discovery of epigenetic changes critical to cell type-specific differentiation. Although iPS cells have been generated from other terminally differentiated cells, the reprogramming of normal adult human basal prostatic epithelial (E-PZ) cells to a pluripotent state has not been reported. Here, we attempted to reprogram E-PZ cells ...

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ژورنال

عنوان ژورنال: Cell Research

سال: 2010

ISSN: 1001-0602,1748-7838

DOI: 10.1038/cr.2010.127